NICE guideline “Ectopic pregnancy and miscarriage”: new changes and importance for the clinicist

The purpose of this publication is to summarize the current data on effectiveness progestogens in patients with threatened miscarriage (vaginal bleeding first trimester pregnancy) and review updated UK National Institute for Health Care Excel (NICE) clinical guidelines ectopic pregnancy miscarriage.In accordance opinion Cochrane Society experts NICE 2021, vaginal progesterone at a dose 800 mg/day only intervention that has been shown be effective increasing live births compared placebo women one or more previous miscarriages early (relative risk 1.08, 95% confidence interval 1.02–1.15, high certainty evidence). Upon confirmation fetal heartbeat, treatment should extended until 16 weeks gestation.There still uncertainty over safety alternative progestogen treatments (as dydrogesterone) recurrent miscarriage. There also no evidence benefit any other preparations doses